Cyclophilin A in Arrhythmogenic Cardiomyopathy Cardiac Remodeling

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Defining "culprit mechanisms" in arrhythmogenic cardiac remodeling.

There has been increasing awareness of the importance of arrhythmogenic remodeling in the pathophysiology of cardiac arrhythmias.1–3 Arrhythmogenic remodeling, involving acquired changes in cardiac structure or function that promote the occurrence of cardiac arrhythmias, occurs in a wide variety of paradigms including congestive heart failure (CHF), atrial fibrillation (AF), hypertensive cardia...

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Arrhythmogenic cardiomyopathy

Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder, predisposing to sudden cardiac death, particularly in young patients and athletes. Pathological features include loss of myocytes and fibrofatty replacement of right ventricular myocardium; biventricular involvement is often observed. It is a cell-to-cell junction cardiomyopathy, typically caused by genetically determined abno...

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Cardiac myotonic dystrophy mimicking arrhythmogenic right ventricular cardiomyopathy in a young sudden cardiac death victim.

An 11-year-old girl sitting in the kitchen suddenly complained of dizziness. Seconds later, she collapsed and had cardiac arrest. Cardiopulmonary resuscitation was initiated immediately but was unsuccessful, despite prolonged efforts. The girl was previously healthy and had never experienced any cardiac or muscular symptoms. At autopsy, the gross examination was normal. The heart weighed 230 g;...

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Arrhythmogenic cardiomyopathy. Patterns of ventricular involvement using cardiac magnetic resonance

INTRODUCTION AND OBJECTIVES Biventricular arrhythmogenic cardiomyopathy and left dominant arrhythmogenic cardiomyopathy forms had recently been included in the spectrum of arrhythmogenic cardiomyopathy. The aim of the study was to describe, using cardiovascular magnetic resonance, the patterns of ventricular involvement as well as late gadolinium enhancement in these conditions. METHODS Medic...

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Sudden cardiac death owing to arrhythmogenic right ventricular cardiomyopathy

BACKGROUND AND OBJECTIVE Arrhythmogenic right ventricular cardiomyopathy (ARVC) is increasingly recognized in forensic practice with controversial diagnosis. Here we described the epidemiological characteristics and reported the pathogenetic mechanism, diagnostic challenges, and forensic implications of Chinese ARVC autopsy cases. METHODS Two cases of sudden cardiac death owing to ARVC were r...

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2019

ISSN: 1422-0067

DOI: 10.3390/ijms20102403